品名

二環(huán)己胺; Dicyclohexylamine; N,N-Dicyclohexylamine; N-Cyclohexyl cyclohexanamine; CAS：101-83-7

理化性質(zhì)

無色液體。有魚腥味。分子式C12-H23-N。分子量181.31。相對(duì)密度0.9104(25/25℃)。凝固點(diǎn)-0.1℃。沸點(diǎn)256℃。閃點(diǎn)>98.89℃(開杯)。蒸氣密度6.27。稍溶于水; 溶于通常有機(jī)溶劑; 與環(huán)已胺混溶。強(qiáng)堿性。遇熱、明火、氧化劑會(huì)燒。加熱分解,生成氮氧化物。

接觸機(jī)會(huì)

用于制藥、防銹劑、染料、表面活性劑、殺蟲劑、增塑劑、橡膠; 是生產(chǎn)己內(nèi)酰胺的中間產(chǎn)物。在生產(chǎn)中,二環(huán)己胺與環(huán)己胺同時(shí)存在。

國(guó)內(nèi)主要生產(chǎn)廠商:沈陽有機(jī)化工廠

侵入途徑

可經(jīng)呼吸道、消化道和皮膚吸收。

毒理學(xué)簡(jiǎn)介

大鼠經(jīng)口LD50: 373 mg/kg。小鼠經(jīng)口LD50: 500 mg/kg。

二環(huán)己胺經(jīng)口毒性屬中等毒類,吸入毒性屬高毒類。人經(jīng)口MLD為50mg/kg。

二環(huán)己胺蒸氣為致痙攣毒物。對(duì)小鼠的LC100為250mg/m^3,MLC為150mg/m^3。中毒動(dòng)物表現(xiàn)為躁動(dòng)不安和強(qiáng)直性陣發(fā)性痙攣,1-2小時(shí)內(nèi)死亡。小鼠在150mg/m^3濃度吸入40分鐘,中樞神經(jīng)系統(tǒng)閾下刺激的綜合能力無改變。以液體20mg涂兔皮可致壞死,經(jīng)2～4周愈合。以1% 液體反復(fù)涂布豚鼠皮膚,未發(fā)生過敏反應(yīng)。

臨床表現(xiàn)

未見急性中毒病例報(bào)道。

美國(guó)HSDB專家小組評(píng)審：

*SKIN IRRITANT & POSSIBLE SENSITIZER. [R2]

*SYSTEMIC EFFECTS IN MAN INCL NAUSEA & VOMITING, ANXIETY, RESTLESSNESS & DROWSINESS. /CYCLOHEXYLAMINE/ [R12]

*HUMAN LYMPHOCYTE CULTURES EXPOSED TO 4 COMPD @ 3 CONCN (10-3, 10-4 & 10-5 MOLAR) DURING FINAL 5 & 25 HR OF CULTURE. RESULTS CONFIRM THAT CYCLAMATE & CYCLOHEXYLAMINE @ HIGH CONCN CAN INDUCE CHROMOSOME ABERRATIONS. N-HYDROXYCYCLOHEXYLAMINE & DICYCLOHEXYLAMINE HAVE SIMILAR EFFECTS. [R13]

*ENHANCED FREQUENCIES OF GAPS & BREAKS FOLLOWING TREATMENT OF HUMAN LEUKOCYTE CULTURES WITH DICYCLOHEXYLAMINE SULFATE. ABERRATION FREQUENCIES IN CONTROLS ABOUT 6% & 2-FOLD & 3-FOLD INCR IN CHROMATID DAMAGE WITH INT & HIGHER DOSES OF ALL TEST COMPD. EXPOSURE TIMES AS SHORT AS 5 HR. [R14]

*STRONG IRRITANT TO SKIN & MUCOUS MEMBRANES. [R6]

*THIRTY-FIVE TO FORTY PER CENT OF SODIUM SALT OF CYCLOHEXAMIC ACID IS ELIMINATED THROUGH KIDNEYS. UP TO 40% IS CHANGED INTO CYCLOHEXAMINE IN HUMANS & TO LESSER EXTENT INTO DICYCLOHEXAMINE, WHICH IS CARCINOGENIC. [R15]

處理

對(duì)癥治療。

標(biāo)準(zhǔn)

車間空氣衛(wèi)生標(biāo)準(zhǔn)：

俄羅斯: STEL 1 mg/m3, 皮膚

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